Kenneth McLeod, Albert Burger:
Towards the use of Argumentation in Bioinformatics: A Gene Expression Case Study.
Abstract
Motivation: Due to different experimental setups and various
interpretations of results, the data contained in online bioinformatics
resources can be inconsistent, therefore, making it more difficult for
users of these resources to assess the suitability and correctness of the
answers to their queries. This work investigates the role of argumentation
systems to help users evaluate such answers. More specifically, it looks
closely at a gene expression case study, creating an appropriate
representation of the underlying data and series of rules that are used by
a third-party argumentation engine to reason over the query results
provided by the mouse gene expression database EMAGE.
Results: A prototype using the ASPIC argumentation engine has been implemented
and a preliminary evaluation carried out. This evaluation suggested that
argumentation can be used to deal with inconsistent data in biological
resources.
Availability: The ASPIC argumentation engine is available from
http://www.argumentation.org. EMAGE gene expression data can be obtained
from http://genex.hgu.mrc.ac.uk. The argumentation rules for the gene
expression example are available from the lead author upon request.
URL:
http://rewerse.net/publications/rewerse-publications.html#REWERSE-RP-2008-030
@inproceedings{REWERSE-RP-2008-030, author = {Kenneth McLeod and Albert Burger}, title = {Towards the use of Argumentation in Bioinformatics: A Gene Expression Case Study}, booktitle = {Proceedings of 16th Annual International Conference Intelligent Systems for Molecular Biology, Toronto, Canada (19th--23rd July 2008)}, year = {2008}, volume = {24}, number = {13}, organization = {ISCB}, pages = {i304--i312}, url = {http://rewerse.net/publications/rewerse-publications.html#REWERSE-RP-2008-030} }